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Akio Shimizu Selected Research

Neuropilin-2

5/2011Hypoxia induces tumor and endothelial cell migration in a semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor neuropilin 2.
8/2010A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression.
1/2008Semaphorin-induced cytoskeletal collapse and repulsion of endothelial cells.
11/2004Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype.

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Akio Shimizu Research Topics

Disease

17Neoplasms (Cancer)
05/2022 - 11/2004
9Neoplasm Metastasis (Metastasis)
10/2021 - 11/2004
7Deglutition Disorders (Dysphagia)
12/2021 - 05/2010
4Sarcopenia
10/2022 - 05/2018
4Malnutrition (Nutritional Deficiencies)
04/2022 - 12/2019
3Stroke (Strokes)
04/2022 - 12/2021
3Glioblastoma (Glioblastoma Multiforme)
05/2014 - 05/2011
3Melanoma (Melanoma, Malignant)
05/2011 - 08/2010
2Inflammation (Inflammations)
10/2022 - 01/2016
2Edema (Dropsy)
05/2022 - 10/2019
2Fibrosis (Cirrhosis)
11/2017 - 01/2017
2Brain Neoplasms (Brain Tumor)
01/2013 - 02/2012
1Frailty
05/2022
1Head and Neck Neoplasms (Head and Neck Cancer)
05/2022
1Anorexia
03/2022
1Dysarthria (Spastic Dysarthria)
10/2021
1Velopharyngeal Insufficiency
10/2021
1Cranial Nerve Diseases (Cranial Nerve Disorders)
10/2021
1Metabolic Bone Diseases (Osteopenia)
01/2021
1Osteoporosis
01/2021
1Kallmann Syndrome (Kallmann's Syndrome)
01/2020
1Anosmia
01/2020
1Brugada Syndrome
01/2020
1Hypogonadism (Hypergonadotropic Hypogonadism)
01/2020
1Atrial Fibrillation
01/2019
1Bradycardia
01/2019
1Prostatic Neoplasms (Prostate Cancer)
10/2018
1Cardiomegaly (Heart Hypertrophy)
11/2017
1Left Ventricular Dysfunction
11/2017
1Heart Failure
11/2017
1Virus Diseases (Viral Diseases)
02/2016
1Hypertension (High Blood Pressure)
01/2016
1Carcinoma (Carcinomatosis)
01/2016
1Adenocarcinoma
01/2016
1Esophageal Squamous Cell Carcinoma
01/2016
1Carcinogenesis
01/2016
1Skin Neoplasms (Skin Cancer)
07/2015
1Non-alcoholic Fatty Liver Disease
06/2015
1Liver Diseases (Liver Disease)
06/2015
1Fatty Liver
06/2015
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
07/2014
1Neurilemmoma (Schwannoma)
02/2012

Drug/Important Bio-Agent (IBA)

7Proteins (Proteins, Gene)FDA Link
10/2022 - 01/2008
7Semaphorins (Semaphorin)IBA
05/2014 - 11/2004
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2018 - 08/2010
4Neuropilin-2IBA
05/2011 - 11/2004
3Monomeric GTP-Binding ProteinsIBA
10/2021 - 04/2018
2epithelial membrane protein-1IBA
10/2021 - 10/2018
2Indicators and Reagents (Reagents)IBA
03/2021 - 10/2019
2Actins (F Actin)IBA
05/2011 - 01/2008
1Serum AlbuminIBA
05/2022
1C-Reactive ProteinIBA
05/2022
1Biological ProductsIBA
10/2021
1Biomarkers (Surrogate Marker)IBA
02/2021
1Glycoproteins (Glycoprotein)IBA
01/2020
1Membrane Proteins (Integral Membrane Proteins)IBA
10/2019
1Potassium Channels (Potassium Channel)IBA
01/2019
1NIP 151IBA
01/2019
1copine IIIIBA
10/2018
1Growth Differentiation Factor 15IBA
11/2017
1afadinIBA
11/2017
14- (5- benzo(1,3)dioxol- 5- yl- 4- pyridin- 2- yl- 1H- imidazol- 2- yl)benzamideIBA
01/2017
1Immunologic Adjuvants (Immunologic Adjuvant)IBA
02/2016
1Poly I-CIBA
02/2016
1LipopolysaccharidesIBA
02/2016
1Tumor Biomarkers (Tumor Markers)IBA
01/2016
1dipeptidyl peptidase IIIIBA
01/2016
1Protein Isoforms (Isoforms)IBA
01/2016
1Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA
01/2016
1LigandsIBA
01/2016
1AlbuminsIBA
01/2016
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
01/2016
1Alcohol Dehydrogenase (Alcohol Dehydrogenase (NAD+))IBA
06/2015
1Choline (Choline Chloride)IBA
06/2015
1Glutathione (Reduced Glutathione)IBA
06/2015
1Methionine (L-Methionine)FDA Link
06/2015
1Neuropilin-1IBA
07/2014
1Imatinib Mesylate (Gleevec)FDA Link
05/2014
1Phosphotransferases (Kinase)IBA
05/2014
1Tyrosine Kinase InhibitorsIBA
05/2014
1Semaphorin-3AIBA
05/2014
1matrigelIBA
01/2013
1Netrin-1IBA
01/2013
1Cathepsin BIBA
01/2013
1EnzymesIBA
01/2013
1Annexin A2 (Annexin II)IBA
01/2013
1Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA
01/2013
1Cysteine Proteases (Cysteine Protease)IBA
01/2013
1Neurofibromin 2 (Merlin)IBA
02/2012
1Deferoxamine (Desferal)FDA LinkGeneric
05/2011

Therapy/Procedure

6Activities of Daily Living (ADL)
05/2022 - 05/2018
4Therapeutics
05/2022 - 01/2013
2Length of Stay
01/2021 - 12/2019
1Radiotherapy
05/2022
1Palliative Care (Palliative Therapy)
05/2022
1Foot Orthoses
03/2022
1Dentures
03/2022
1Stroke Rehabilitation
12/2021
1Gastrostomy
12/2021
1Prostheses and Implants (Prosthesis)
10/2021